http://nutrisuplaw.com/good-news-bad-news-and-more-bad-news-on-vitamins/ Dietary supplements, nutraceuticals, functional foods and drinks, cosmetics, and the law. Sat, 13 Mar 2010 01:04:41 +0000 http://wordpress.org/?v=2.9.2 hourly 1 http://nutrisuplaw.com/good-news-bad-news-and-more-bad-news-on-vitamins/comment-page-1/#comment-2442 Hugo Ottolenghi Mon, 23 Nov 2009 20:47:18 +0000 http://nutrisuplaw.com/?p=1405#comment-2442 Thank you for the details, David. As you point out, there is confusion. The general media are adding to that with unqualified headlines saying folic acid can be harmful. Thank you for the details, David. As you point out, there is confusion. The general media are adding to that with unqualified headlines saying folic acid can be harmful.

]]> http://nutrisuplaw.com/good-news-bad-news-and-more-bad-news-on-vitamins/comment-page-1/#comment-2440 David A. Mark Mon, 23 Nov 2009 14:25:47 +0000 http://nutrisuplaw.com/?p=1405#comment-2440 Item #3 was more complicated than that. It was done in Norway, 70% either current smokers or former smokers, and combined folic acid at 800 ug/d with vitamin B12 at 400 ug/day. The study saw an uptick in all cancer but that was mostly due to lung cancer and not colorectal cancer; earlier studies had seen upticks in colorectal, breast and prostate cancer, but no mention of lung. Within the JAMA study the authors note that all got the same doses, but only those that responded with a high serum folate were at higher risk. And then, two days after the JAMA article, a different study by Wu et al in AJCN reported a trend for lower recurrence of adenoma after years of folic acid at 1000 ug/d, with a better response in the subset that had started with low serum folate. Clearly, the consequences of folic acid fortification and supplement taking are confusing, complex, and likely involve a genetic component. Item #3 was more complicated than that. It was done in Norway, 70% either current smokers or former smokers, and combined folic acid at 800 ug/d with vitamin B12 at 400 ug/day. The study saw an uptick in all cancer but that was mostly due to lung cancer and not colorectal cancer; earlier studies had seen upticks in colorectal, breast and prostate cancer, but no mention of lung. Within the JAMA study the authors note that all got the same doses, but only those that responded with a high serum folate were at higher risk. And then, two days after the JAMA article, a different study by Wu et al in AJCN reported a trend for lower recurrence of adenoma after years of folic acid at 1000 ug/d, with a better response in the subset that had started with low serum folate. Clearly, the consequences of folic acid fortification and supplement taking are confusing, complex, and likely involve a genetic component.

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